RNA Structure Duplications and Flavivirus Host Adaptation
摘要：
Recent advances in molecular virology provide new hypotheses of how RNA structures in mosquito-borne flavivirus genomes mediate host adaptation, viral replication, and evasion of antiviral responses. Dengue virus RNA structures play different functions during infection in vertebrate and invertebrate hosts. Conflicting requirements of viral RNA elements shape the composition of viral populations obtained in human or mosquito cells. Viral RNA structures can modulate the type and extent of host antiviral responses. Complex RNA structures present at the viral 3′ untranslated region (3′ UTR) that stall the host exoribonuclease XRN1 and generate small virus-derived RNAs are duplicated in mosquito-borne flaviviruses. Conservation of RNA structure duplication in the 3′ UTR of insect-borne viruses is associated with mechanisms of host adaptation.
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DOI：
10.1016/j.tim.2016.01.002
被引量：
年份：
2016
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