摘要：

Thiosemicarbazones of α-(N)-heterocyclic ketones and aldehydes possess a broad spectrum of potentially useful chemotherapeutic activities. Thus, the antimalarial, antibacterial, and antiviral properties of this class have been explored by Klayman, et al.1 The antileishmanial activity of a series of acetyl β-carboline thiosemicarbazones was recently described by Dodd and coworkers .2 The α-(N)-heterocyclic thiosemicarbazones act as tridentate ligands for transition metals3; this property has been implicated in their biological mechanism of action.4 The synthesis thiosemicarbazone-transition metal complexes and the spectroscopic investigation of structure and bonding in these complexes is being actively pursued 5 In order to facilitate these investigations, an improved method of

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