CD44 is the principal cell surface receptor for hyaluronate.
摘要：
CD44 is a broadly distributed cell surface protein thought to mediate cell attachment to extracellular matrix components or specific cell surface ligands. We have created soluble CD44-immunoglobulin fusion proteins and characterized their reactivity with tissue sections and lymph node high endothelial cells in primary culture. The CD44 target on high endothelial cells is sensitive to enzymes that degrade hyaluronate, and binding of soluble CD44 is blocked by low concentrations of hyaluronate or high concentrations of chondroitin 4- and 6-sulfates. A mouse anti-hamster hyaluronate receptor antibody reacts with COS cells expressing hamster CD44 cDNA. In sections of all tissues examined, including lymph nodes and Peyer's patches, predigestion with hyaluronidase eliminated CD44 binding.
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关键词：
HUMAN GROWTH HORMONE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY ACROMEGALY RADIOIMMUNOASSAY MOLECULAR FORMS HGH PROTEINS HGH-BINDING SIZE EXCLUSION CHROMATOGRAPHY
DOI：
10.1016/0092-8674(90)90694-A
被引量：
年份：
1990
Elsevier
Taylor & Francis
BMJ
Wiley
万方医学
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