3-Hydroxycoumarins: first direct preparation from coumarins using a Cu2(+)-ascorbic acid-O2 system, and their potent bioactivities
摘要：
First direct 3-hydroxylation of a coumarin ring via a purely chemical system, previously only possible using cytochrome P-450, was successfully conducted by a Cu 2+-ascorbic acid-O 2 system; the two 3-hydroxycoumarins obtained were novel compounds, 3-hydroxyscopoletin and 3-hydroxyisoscopoletin. 5-Lipoxygenase and α-D-glucosidase inhibitory activities of coumarins greatly increased through 3-hydroxylation. 3-Hydroxyscopoletin and 3-hydroxyumbelliferone had a high inhibitory potency for 5-lipoxygenase and for α-D-glucosidase respectively; they serve as lead compounds for new drugs.
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关键词：
TLC thin layer chromatography thin layer chromatography HPLC high performance liquid chromatography high performance liquid chromatography UV ultraviolet ultraviolet IR infrared infrared NMR nuclear magnetic resonance nuclear magnetic resonance
DOI：
10.1016/0006-291X(90)91689-P
被引量：
年份：
1990
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