登录注册
高级搜索
包含全部检索词
包含精确检索词
包含至少一个检索词
不包含检索词
出现检索词的位置
文章任何位置
位于文章标题
作者
机构
出版物 期刊
会议
发表时间  - 
语言检索范围 不限
不限 英文 中文
文献
期刊
学者
论文查重 首单免费
开题分析
单篇购买
文献互助

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues

来自 掌桥科研

阅读量：

81

作者：

A Lundby，A Secher，K Lage，NB Nordsborg，A Dmytriyev，C Lundby，JV Olsen

展开

摘要：

Deregulated cellular signalling is a common hallmark of disease, and delineating tissue phosphoproteomes is key to unravelling the underlying mechanisms. Here we present the broadest tissue catalogue of phosphoproteins to date, covering 31,480 phosphorylation sites on 7,280 proteins quantified across 14 rat organs and tissues. We provide the data set as an easily accessible resource via a web-based database, the CPR PTM Resource. A major fraction of the presented phosphorylation sites are tissue-specific and modulate protein interaction networks that are essential for the function of individual organs. For skeletal muscle, we find that phosphotyrosines are over-represented, which is mainly due to proteins involved in glycogenolysis and muscle contraction, a finding we validate in human skeletal muscle biopsies. Tyrosine phosphorylation is involved in both skeletal and cardiac muscle contraction, whereas glycogenolytic enzymes are tyrosine phosphorylated in skeletal muscle but not in the liver. The presented phosphoproteomic method is simple and rapid, making it applicable for screening of diseased tissue samples.

展开

关键词：

Leishmaniasis Phlebotomus (Phlebotomus) salehi sandfly Sri Lanka vector

DOI：

10.1038/ncomms1871

被引量：

266

年份：

2012

收藏 引用 批量引用 分享
全部来源 免费下载 求助全文

通过文献互助平台发起求助，成功后即可免费获取论文全文。

相似文献

参考文献

引证文献

来源期刊

Nature Communications
2012-06-06 00:00:00.0

研究点推荐

引用走势

2014
被引量：73

辅助模式

0

引用

文献可以批量引用啦~
欢迎点我试用！

引用