A critical role of RICK/RIP2 polyubiquitination in Nod‐induced NF‐κB activation
摘要：
Nod1 and Nod2 are intracellular proteins that are involved in host recognition of specific bacterial molecules and are genetically associated with several inflammatory diseases. Nod1 and Nod2 stimulation activates NF-B through RICK, a caspase-recruitment domain-containing kinase. However, the mechanism by which RICK activates NF-B in response to Nod1 and Nod2 stimulation is unknown. Here we show that RICK is conjugated with lysine-63-linked polyubiquitin chains at lysine 209 (K209) located in its kinase domain upon Nod1 or Nod2 stimulation and by induced oligomerization of RICK. Polyubiquitination of RICK at K209 was essential for RICK-mediated IKK activation and cytokine/chemokine secretion. However, RICK polyubiquitination did not require the kinase activity of RICK or alter the interaction of RICK with NEMO, a regulatory subunit of IB kinase (IKK). Instead, polyubiquitination of RICK was found to mediate the recruitment of TAK1, a kinase that was found to be essential for Nod1-induced signaling. Thus, RICK polyubiquitination links TAK1 to IKK complexes, a critical step in Nod1/Nod2-mediated NF-B activation.
展开
DOI：
10.1038/sj.emboj.7601962
被引量：
年份：
2008
BMJ
Nature
国家科技图书文献中心
(权威机构)
EBSCO
Wiley
(全网免费下载)
查看更多
Wiley
万方
Semantic Scholar
掌桥科研
万方医学
dx.doi.org
NCBI
NCBI
Europe PMC
(全网免费下载)
Europe PMC
Oxford Univ Press
JBC
ProQuest
ResearchGate
ResearchGate
(全网免费下载)
EBSCO
Citeseer
(全网免费下载)
deepdyve.com
mendeley.com
core.ac.uk
embojnl.embopress.org
(全网免费下载)
hw-f5-embojnl.highwire.org
atvb.ahajournals.org
emboj.embopress.org
rsob.royalsocietypublishing.org
jem.rupress.org
deepblue.lib.umich.edu
(全网免费下载)
SAGE
cshperspectives.cshlp.org
jleukbio.org
ar.iiarjournals.org
scienceopen.com
bvsalud.org
hdl.handle.net
deepblue.lib.umich.edu
jcs.biologists.org
jimmunol.org
onAcademic
pubfacts.com
emboj.embopress.org
(全网免费下载)
advan.physiology.org
readcube.com
growkudos.com
Wiley
(全网免费下载)
Europe PMC
(全网免费下载)
ResearchGate
(全网免费下载)
Citeseer
(全网免费下载)
embojnl.embopress.org
(全网免费下载)
deepblue.lib.umich.edu
(全网免费下载)
emboj.embopress.org
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
