Induction of self-tolerance in mature peripheral B lymphocytes
摘要：
In transgenic mice, mature peripheral B lymphocytes in lymphoid follicles, like immature B cells, are rendered tolerant by encounter with self-antigen, provided receptor occupancy by self-antigen exceeds a critical threshold. The tolerant state of the B cell is closely correlated with down-regulation of membrane IgM but not IgD antigen-receptors. Identical changes in antigen-receptor expression occur in a subset of follicular B cells in nontransgenic mice, suggesting that clonally silenced self-reactive cells are common in the peripheral B-cell repertoire.
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关键词：
Animals Mice, Inbred C57BL Mice B-Lymphocytes Zinc Immunoglobulin D Immunoglobulin M Muramidase Receptors, Immunologic Receptors, Fc
DOI：
10.1038/342385a0
被引量：
年份：
1989
BMJ
Springer
Nature
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Wiley
万方医学
万方医学
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NCBI
Europe PMC
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Oxford Univ Press
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ProQuest
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EBSCO
jvi.asm.org
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