Studies of enzyme-mediated reactions. Part III. Stereoselective labelling at C-2 of tyramine: stereochemistry of hydroxylation at saturated carbon
摘要：
Synthetic routes to tyramine have been developed which allow stereoselective labelling with isotopic hydrogen at C-2 in configurations established by chemical correlation with [2-2H1]succinic acid of known absolute configuration. The various labelled tyramines have been converted into samples of O-methylnorbelladine [as (33)] which are used to prove that the hydroxylation step at saturated carbon in haemanthamine biosynthesis occurs (a) stereo-specifically with removal of the pro-R hydrogen atom and (b) with retention of configuration.
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DOI：
10.1002/chin.197344210
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年份：
1973
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来源期刊
Journal of the Chemical Society Perkin Transactions
October 30, 1973
引用走势
1975
被引量：1
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