CDC25 phosphatases as potential human oncogenes
摘要：
Cyclin-dependent kinases (CDKs) are activated by CDC25 phosphatases, which remove inhibitory phosphate from tyrosine and threonine residues. In human cells, CDC25 proteins are encoded by a multigene family, consisting of CDC25A, CDC25B, and CDC25C. In rodent cells, human CDC25A or CDC25B but not CDC25C phosphatases cooperate with either Ha-RAS$^{G12V}$ or loss of RB1 in oncogenic focus formation. Such transformants were highly aneuploid, grew in soft agar, and formed high-grade tumors in nude mice. Overexpression of CDC25B was detected in 32 percent of human primary breast cancers tested. The CDC25 phosphatases may contribute to the development of human cancer.
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关键词：
Fission yeast Breast carcinoma Mitotic inducer P34cdc2 kinase Cdk2 activity Cyclin Phosphorylation Cells Activation Inhibition
DOI：
10.1126/science.7667636
被引量：
年份：
1995
掌桥科研
Semantic Scholar
万方医学
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