Molecular profiling of non-small cell lung cancer and correlation with disease-free survival.
摘要：
Recent studies have suggested that information from gene expression profiles could be used to develop molecular classifications of cancer. We hypothesized that expression levels of specific genes in operative specimens could be correlated to recurrence risk in non-small cell lung cancer (NSCLC). We performed expression profiling using 19.2 K cDNA microarrays on tumor specimens from a total of 39 NSCLC patients with known clinical follow-up information. Statistical analysis and clustering approaches were used to determine patterns of gene expression segregating with clinical outcome. The results provide evidence that molecular subtyping of NSCLC can identify distinct profiles of gene expression correlating with disease-free survival.
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关键词：
Humans Carcinoma, Non-Small-Cell Lung Lung Neoplasms Disease-Free Survival Oligonucleotide Array Sequence Analysis Gene Expression Profiling Multigene Family Adult Aged Middle Aged
DOI：
10.1097/00002820-200206000-00013
被引量：
年份：
2002
Wiley
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万方医学
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