摘要：

Direct catalytic aldol reactions of 伪,伪-dialkylaldehyde donors and arylaldehyde acceptors have been performed using pyrrolidine鈭抋cetic acid bifunctional catalysts. This general and practical amine鈭抋cid combination was identified by screening catalysts using a new fluorescent detection system for carbon鈭抍arbon bond formation. Using 0.05 equiv of pyrrolidine and 0.25 equiv of acetic acid as catalyst, we obtained 伪,伪-dialkylaldol product in 96% yield after 2 h at ambient temperature. Proline was a poor catalyst of this reaction.

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