ASSOCIATION BETWEEN CARDIOVASCULAR DEATH AND MYOCARDIAL INFARCTION AND SERUM SELENIUM IN A MATCHED-PAIR LONGITUDINAL STUDY

来自 dx.doi.org

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作者：

JukkaT Salonen a，Georg Alfthan b，JussiK Huttunen b，Jarmo Pikkarainen b，Pekka Puska b

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摘要：

A case-control study was conducted to investigate the association between serum selenium and risk of death from acute coronary heart disease (CHD) as well as risk of fatal and non-fatal myocardial infarction (MI). Case-control pairs came from a population of 11 000 persons examined in 1972 from two counties in eastern Finland, an area with an exceptionally high mortality from cardiovascular diseases. Cases were aged 35-59 years and had died of CHD or other CVD or had a non-fatal MI during a seven-year follow-up. Controls were matched for sex, age, daily tobacco consumption, serum cholesterol, diastolic blood pressure, and history of angina pectoris. The mean serum selenium concentration for all cases was 51·8 μg/l and for all controls 55·3 μg/l(p<0·01). Serum selenium of less than 45 μg/l was associated with an adjusted relative risk of CHD death of 2·9 (p<0·01, 95% CI, 1·4-6·0), a relative risk of CVD death of 2·2 (p<0·01, 95% CI, 1·2-4·0), and a relative risk of fatal and nonfatal MI of 2·1 (p<0·001, 95% CI, 1·4-3·1). 22% (95% CI, 8-35%) of coronary deaths were attributable to serum selenium in the whole study population.

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关键词：

Mortality Causes of Death Cardiovascular Effects Heart Diseases Nutrition Matched Groups Longitudinal Studies Developed Countries Population Dynamics Demographic Factors