Epidermal Langerhans cells are derived from cells originating in bone marrow

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Langerhans cells constitute a morphologically well characterised subpopulation (3–8%) of mammalian epidermal cells which, in contrast to the bulk of epidermal cells, bear Fc-IgG and C3 receptors 1 , express immune response-associated (Ia) antigens and function as antigen-presenting cells and allogeneic stimulatory cells to primed T lymphocytes 2–5 . The ontogeny of Langerhans cells has been a subject of considerable debate since their discovery 6 . Although some studies suggest that Langerhans cells are of mesenchymal as opposed to neural or melanocytic origin 7 , direct evidence for this has not been presented. In this study we demonstrate that, after 3 weeks, most of the Langerhans cells (LC) in parental skin which had been transplanted on to F 1 hybrids were of recipient origin whereas keratinocytes remained of donor origin; this indicates that the LC are derived from a mobile pool of cells. Furthermore, in studies of skin from radiation-induced bone marrow chimaeric animals we found that, depending on the strain combination, up to 80% of the epidermal LC were derived from the bone marrow of the donor animals.

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Bone Marrow Animals Mice, Inbred Strains Mice Epidermis Langerhans Cells Bone Marrow Cells Histocompatibility Antigens Cell Differentiation Major Histocompatibility Complex