摘要：

The enantioselective cyclopropanation of cinnamyl alcohol ( 3) to 2-phenylcyclopropanemethanol ( 4) using (1 R,2 S)- N-methylephedrine-modified halomethylzinc reagents is reported. Modest (up to 24% ee) enantioselectivites were observed, and a solvent induced reversal of selectivity was noted. These studies demonstrated the potential for chiral zinc species to differentiate olefin enantiofaces in the delivery of methylene to prochiral allylic alcohols.

展开