The neglected role of insulin-like growth factors in the maternal circulation regulating fetal growth
摘要：
Maternal insulin-like growth factors (IGFs) play a pivotal role in modulating fetal growth via their actions on both the mother and the placenta. Circulating IGFs influence maternal tissue growth and metabolism, thereby regulating nutrient availability for the growth of the conceptus. Maternal IGFs also regulate placental morphogenesis, substrate transport and hormone secretion, all of which influence fetal growth either via indirect effects on maternal substrate availability, or through direct effects on the placenta and its capacity to supply nutrients to the fetus. The extent to which IGFs influence the mother and/or placenta are dependent on the species and maternal factors, including age and nutrition. As altered fetal growth is associated with increased perinatal morbidity and mortality and a greater risk of developing degenerative diseases in adult life, understanding the role of maternal IGFs during pregnancy is essential in order to identify mechanisms underlying altered fetal growth and offspring programming.
展开
关键词：
Fetus Placenta Animals Humans Somatomedins Maternal-Fetal Exchange Energy Metabolism Placental Circulation Fetal Development Maternal Nutritional Physiological Phenomena
DOI：
10.1113/jphysiol.2010.198622
被引量：
年份：
2011
国家科技图书文献中心
(权威机构)
Wiley
(全网免费下载)
Wiley
Wiley
EBSCO
查看更多
掌桥科研
Semantic Scholar
(全网免费下载)
Semantic Scholar
dx.doi.org
NCBI
NCBI
(全网免费下载)
Europe PMC
(全网免费下载)
NCBI
Europe PMC
ResearchGate
(全网免费下载)
ResearchGate
Citeseer
(全网免费下载)
EBSCO
core.ac.uk
science-open.com
(全网免费下载)
scienceopen.com
(全网免费下载)
onlinecjc.ca
onAcademic
frontiersin.org
endocrineconnections.com
mysciencework.com
digital.library.adelaide.edu.au
deepdyve.com
hdl.handle.net
nova.newcastle.edu.au
mendeley.com
bvsalud.org
science-open.com
biomedsearch.com
(全网免费下载)
学术范
jp.physoc.org
学术范
(全网免费下载)
Wiley
(全网免费下载)
Semantic Scholar
(全网免费下载)
Europe PMC
(全网免费下载)
NCBI
(全网免费下载)
ResearchGate
(全网免费下载)
Citeseer
(全网免费下载)
biomedsearch.com
(全网免费下载)
scienceopen.com
(全网免费下载)
学术范
(全网免费下载)
science-open.com
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
