Role of epithelial cells in idiopathic pulmonary fibrosis: from innocent targets to serial killers.
摘要：
Idiopathic pulmonary fibrosis (IPF), a progressive and relentless lung scarring of unknown etiology, has been recognized as the most lethal interstitial lung disease. Despite the growing interest in IPF, the precise molecular mechanisms underlying the development of fibrosis and leading to the irreversible destruction of the lung are still unknown. Recently, it has been proposed that IPF, instead of being a chronic inflammatory disorder, results from multiple cycles of epithelial cell injury and activation. In turn, active alveolar epithelial cells provoke the migration, proliferation, and activation of mesenchymal cells with the formation of fibroblastic/myofibroblastic foci and the exaggerated accumulation of extracellular matrix, mirroring abnormal wound repair. In this article, some characteristics of the alveolar epithelium are briefly outlined, and the fibrogenic mechanisms specifically operated by active abnormal epithelial cells are examined.
展开
关键词：
Pulmonary Alveoli Fibroblasts Epithelial Cells Mesoderm Humans Pulmonary Fibrosis Apoptosis Cell Differentiation Cell Proliferation Cell Movement
DOI：
10.1513/pats.200601-003TK
被引量：
年份：
2006
国家科技图书文献中心
(权威机构)
Wiley
Semantic Scholar
(全网免费下载)
万方医学
dx.doi.org
查看更多
BioOne
NCBI
NCBI
Europe PMC
ResearchGate
Citeseer
Citeseer
(全网免费下载)
atsjournals.org
(全网免费下载)
jacionline.org
学术范
pneumonologia.gr
(全网免费下载)
pneumonologia.gr
(全网免费下载)
mendeley.com
www.socolar.com
cghjournal.org
core.ac.uk
scienceopen.com
deepdyve.com
err.ersjournals.com
pharmrev.aspetjournals.org
pubfacts.com
ajplung.physiology.org
学术范
(全网免费下载)
Semantic Scholar
(全网免费下载)
Citeseer
(全网免费下载)
pneumonologia.gr
(全网免费下载)
pneumonologia.gr
(全网免费下载)
atsjournals.org
(全网免费下载)
学术范
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
来源期刊
引用走势
站内活动
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
