ORIGIN AND FUNCTION OF EPOXYEICOSATRIENOIC ACIDS IN VASCULAR ENDOTHELIAL CELLS: MORE THAN JUST ENDOTHELIUM-DERIVED HYPERPOLARIZING FACTOR?
阅读量:
12
摘要:
SUMMARY1. In addition to their contribution to endothelium-derived hyperpolarization, our understanding of the physiological function of epoxyeicosatrienoic acids (EET) within the vascular wall and the actual enzymes involved in the formation of the EET in endothelial cells is very limited. In the present study, the expression of potential cytochrome P450 (CYP) mono/epoxygenases was assessed in endothelial cells isolated from porcine and bovine aortas as well as in the human umbilical vein-derived cell lines EA.hy926andECV304.
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关键词:
bradykinin capacitative Ca2+ entry cytochrome P450 epoxygenase endothelial cells endothelium-derived hyperpolarizing factor tyrosine kinase.
DOI:
10.1111/j.1440-1681.1998.tb02162.x
被引量:
年份:
1998
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