Protein Nanocapsule Weaved with Enzymatically Degradable Polymeric Network
摘要:
Target proteins can be functionally encapsulated using a cocoon-like polymeric nanocapsule formed by interfacial polymerization. The nanocapsule is cross-linked by peptides that can be proteolyzed by proteases upon which the protein cargo is released. The protease-mediated degradation process can be controlled in a spatiotemporal fashion through modification of the peptide cross-linker with photolabile moieties. We demonstrate the utility of this approach through the cytoplasmic delivery of the apoptosis inducing caspase-3 to cancer cells.
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关键词:
Al-doped ZnO (AZO Direct-current (DC) magnetron sputtering Heterojunction Current-voltage (I-V) characteristics
DOI:
10.1021/nl902935b
被引量:
年份:
2009























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