The Oxidative Inactivation of Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) by Hypochlorous Acid (HOCl) is Suppressed by Anti-Rheumatic Drugs
摘要：
Tissue inhibitors of metalloproteinases (TIMPs) prevent uncontrolled connective tissue destruction by limiting the activity of matrix metalloproteinases (MMPs). That TIMPs should be susceptible to oxidative inactivation is suggested by their complex tertiary structure which is dependent upon 6 disulphide bonds. We examined the oxidative inactivation of human recombinant TIMP-1 (hr TIMP-1) by HOCl and the inhibition of this process by anti-rheumatic agents.
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关键词：
Tissue inhibitor of metalloproteinases (TIMP) oxidants anti-rheumatic drugs and hypochlorous acid
DOI：
10.3109/10715769809065797
被引量：
年份：
1998
Taylor & Francis
Semantic Scholar
万方医学
dx.doi.org
Oxford Univ Press
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