Indications to an NADPH oxidase as a possible pO2 sensor in the rat carotid body.
摘要：
The rat carotid body superfused with low pO 2 exhibited an optical absorbance spectrum which resembles the reduced spectrum of the NADPH oxidase in neutrophils. Diphenylene iodonium (DPI) as a specific inhibitor of the oxidase attenuated the reduced absorbance spectrum in the carotid body. Also absorbance bleaching by low doses of cyanide (50 and 100 μM) was inhibited by DPI, whereas higher doses of cyanide (300 μM) caused an absorbance spectrum typical for reduced cytochromes. It is concluded that an NADPH oxidase acts as a pO 2 sensor in the carotid body with low affinity for oxygen and high affinity for cyanide. Carotid body; pO 2 sensor; NADPH oxidase; Diphenylene iodonium; Light absorbance spectrum; Hypoxia; Cyanide
展开
关键词：
LGIC SUPERFAMILY PROTO-BINDING SITE CYS-LOOP MOTIF DOCKING MODEL ANIONIC SITE SPECIFICITY RESIDUE
DOI：
10.1016/0014-5793(89)81721-1
被引量：
年份：
1989
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
