Relevance of different UGT1A1 polymorphisms in irinotecan-induced toxicity: a molecular and clinical study of 75 patients.
摘要：
We wanted to assess polymorphisms in the uridine diphosphoglucuronosyl transferase 1A1 (UGT 1A1) gene: the TATA box polymorphism and UGT 1A1 G71R and Y486D mutations in the coding sequence, the main mutations characterizing Gilbert's syndrome, as predictors of severe toxic event occurrence after irinotecan (CPT-11) administration. Therefore, we set up a rapid, sensitive, and reliable technique in routine practice to detect before CPT-11 treatment, the at-risk patients.
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关键词：
Humans Colorectal Neoplasms Neoplasm Metastasis Camptothecin Fluorouracil Glucuronosyltransferase DNA Primers Antineoplastic Agents, Phytogenic Antineoplastic Combined Chemotherapy Protocols Risk
DOI：
10.1158/1078-0432.CCR-03-0548
被引量：
年份：
2004
万方医学
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