Substituted azoloquinolines and -quinazolines as new potent farnesyl protein transferase inhibitors.
摘要：
A series of (4-chlorophenyl)-α-(1-methyl-1-imidazol-5-yl)azoloquinolines and -quinazolines was prepared. These compounds displayed potent Farnesyl Protein Transferase inhibitory activity and tetrazolo[1,5-]quinazolines are promising agents for oral in vivo inhibition.The synthesis and inhibiting potency of farnesyltransferase inhibitors derived from R115777 is reported.
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关键词：
fused pyridine derivatives enzyme inhibiting activity ring closure reactions imidazole derivatives triazole derivatives tetrazole derivatives
DOI：
10.1016/j.bmcl.2003.08.080
被引量：
年份：
2003
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