Liposomes and niosomes as topical drug carriers-dermal and transdermal drug delivery
摘要：
A critical analysis of (trans) dermal delivery of substances encapsulated within liposomes and niosomes is presented. Topical liposomes or niosomes may serve as solubilization matrix, as a local depot for sustained release of dermally active compounds, as penetration enhancers, or as rate-limiting membrane barrier for the modulation of systemic absorption of drugs. The mechanism(s) of vesicle-skin interaction and drug delivery are being extensively investigated using radioactive- or fluorescence-labeled marker molecules and drugs, and various electron and (laser) light microscopic visualization techniques, and different models describing the interaction with and fate of vesicles in the skin have been proposed
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关键词：
Liposome Niosome Topical drug delivery Dermal drug delivery Transdermal drug delivery Corticosteroid
DOI：
10.1016/0168-3659(94)90039-6
被引量：
年份：
1994
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