The body weight-walking distance product as related to lung function, anaerobic threshold and peak VO2 in COPD patients.

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摘要：

The product of walking distance and body weight (D·W) mimics the work of walking. We hypothesized the superiority of D·W to walking distance (D) alone in any correlation with lung function, anaerobic threshold (AT) and maximal oxygen uptake ( VO 2max). We further hypothesized that the D·W product for a 6-min walk test (6 MWT) would correlate with the AT and VO 2maxbecause all three are markers of exercise ability. Thirty-three male chronic obstructive pulmonary disease (COPD) patients with mean forced expiratory volume in 1 sec (FEV 1) of 1·2±0·4 l (range 0·58–1·86 l) were enrolled. Six patients were excluded due to inability to achieve a maximal test. Lung function and self-assessed every-day activities using a oxygen–cost diagram were evaluated before entry of the study. A maximal effort ramp-pattern cardiopulmonary exercise test (CPET) and a 6 MWT were conducted in random order. Borg score, heart rate, and O 2saturation with pulse oximetry ( S PO 2) were measured during both exercise tests. VO 2AT and minute ventilation were also measured during the CPET. Correlations were sought between the distance covered in the 6 MWT, and the D·W product with AT, VO 2maxand other variables. The average D and D·W were 456 m and 27·5 kgkm 1, respectively. D·W was superior to D alone when correlated with the VO 2maxand AT determined from the CPET, while modestly correlated with the change ( Δ) in Borg score and Δ S pO 2in the 6 MWT and self-assessed every-day activities. Distance×weight product was correlated with the AT and VO 2max. In addition, D·W was better correlated with diffusing capacity for carbon monoxide and vital capacity than D alone. We conclude that D·W mimics the work of walking better than D and is suggested as a parameter for evaluation of patients' fitness if gas exchange measurements are not available.

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关键词：

6-min walking test cycle ergometer Borg score oxygen–cost diagram AT

DOI：

10.1053/rmed.2001.1115

被引量：

249

年份：

2001