摘要：

Malignant lymphomas (ML) in Kagoshima Prefecture are very characteristic, not only in their high incidence among prefectures in Japan, but also in a variety of clinical and morphological appearances. Our recent study based on the 1007 biopsy materials indicated that 1) the incidence rate per 100,000 population of ML has been markedly increasing, revealing 3.93 in 1970, 5.1 in 1975, 6.26 in 1976 and 9.16 in 1977, 2) the diffuse growth pattern predominated histologically, resulting in poor prognosis, 3) high incidence in the higher age group of the 60s and 70s with a male predominance, and 4) prevalence of cutaneous lymphomas.By the analysis of surface marker of tumor cells, we studied 57 patients with T cell type malignancies and 4 patients with B cell type and 12 patients with null cell lymphoma. The primary involvement of the T cell lymphoma was seen in 31 cases in lymph nodes, 20 in the skin, 4 in the tonsils and 2 in the bone marrow. Histologically, all of the cases showed polymorphous tumor cells with diffuse growth pattern. Cytologically the T cell lymphomas were classified as follows: 11 cases of lymphocytic histiocytic mixed type, 10 cases of immunoblastic type, 6 cases of pleomorphic type with Sternberglike giant cells, 6 cases of so-called reticulum cell type, 6 cases of convoluted lymphoblastic type and 2 cases of mycosis fungoides.Twenty autopsies out of 57 T cell lymphomas revealed that a preferential tumor cell involvement was seen in the spleen, bone marrow, aderenal, lungs and liver, and they had severe herpescomplication in form of interstitial pneumonitis due to pneumocystis carinii, cytomegalo and virus and fungus infections. In addition, metastatic calcification in the lung and kidney resulted from hypercalcemia was observed in 30%.

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