Synthesis of tobacco-specific N-nitrosamines and their metabolites and results of related bioassays.
摘要：
Tobacco-specificN-nitrosamines (TSNA) are the most abundant, strong carcinogens in tobacco smoke. Seven TSNA have been identified in tobacco products:N-nitrosonornicotine (NNN),N-nitrosoanabasine (NAB),N-nitrosoanatabine (NAT), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), 4-(methylnitrosamino)-4-(3-pyridyl)-1-butanol (iso-NNAL), and 4-(methylnitrosamino)-4-3-pyridyl)butyric acid (iso-NNAC). The syntheses of these compounds are reviewed. The syntheses of14C- and3H-labeled NNK as well as metabolites of NNK and NNN are also discussed.
展开
关键词：
synthesis tobacco-specificN-nitrosamines carcinogenicity lung oral cavity pancreas esophagus metabolic activation α-hydroxylation
DOI：
10.3109/10408449609017927
被引量：
年份：
1996
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
来源期刊
引用走势
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
