Synthesis of tobacco-specific N-nitrosamines and their metabolites and results of related bioassays.
摘要：
Tobacco-specificN-nitrosamines (TSNA) are the most abundant, strong carcinogens in tobacco smoke. Seven TSNA have been identified in tobacco products:N-nitrosonornicotine (NNN),N-nitrosoanabasine (NAB),N-nitrosoanatabine (NAT), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), 4-(methylnitrosamino)-4-(3-pyridyl)-1-butanol (iso-NNAL), and 4-(methylnitrosamino)-4-3-pyridyl)butyric acid (iso-NNAC). The syntheses of these compounds are reviewed. The syntheses of14C- and3H-labeled NNK as well as metabolites of NNK and NNN are also discussed.
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关键词：
synthesis tobacco-specificN-nitrosamines carcinogenicity lung oral cavity pancreas esophagus metabolic activation α-hydroxylation
DOI：
10.3109/10408449609017927
被引量：
年份：
1996
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