Adsorption; water swellable

阅读量:

32

公开/公告号:

US5374422 A

公开/公告日期:

Dec 20, 1994

发明人:

LES PierreGR BrownG Wu

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被引量:

103

摘要:

The invention is concerned with novel ingestible cross-linked homopolymers having functional groups consisting of linear or branched amines, of the formula: ##STR1## and their pharmaceutically acceptable salts of the formulae: ##STR2## wherein P(or POLYMER ∥-) represents a hydrophobic, cross-linked and non-digestible homopolymer backbone; R is a hydrogen atom or a lower alkyl radical; X - is a pharmaceutically acceptable anion; m is an integer varying from 1 to 6 inclusive; and n, o and p are, independently, integers varying from 2 to 12 inclusive. The amine functionalized and cross-linked homopolymers of the invention are highly efficient adsorbents for bile acids and salts and can thus be used for reducing hypercholesterolemia in affected humans.

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