Evidence That Human Cardiac Myocytes Divide after Myocardial Infarction.

Background: The scarring of the heart that results from myocardial infarction has been interpreted as evidence that the heart is composed of myocytes that are unable to divide. However, recent observations have provided evidence of proli...

Beltrami，Antonio，P.，... - 《New England Journal of Medicine》

Cytoplasmic signaling pathways that regulate cardiac hypertrophy.

This review discusses the rapidly progressing field of cardiomyocyte signal transduction and the regulation of the hypertrophic response. When stimulated b...

JD Molkentin，DG Nd - 《Annual Review of Physiology》

Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and car...

To determine whether IGF-1 opposes the stimulation of myocyte death in the surviving myocardium after infarction, transgenic mice overexpressing human IGF-...

Q Li，B Li，X Wang，... - 《Journal of Clinical Investigation》

Stretch-mediated release of angiotensin II induces myocyte apoptosis by activating p53 that enhances the local renin-angiotensin system and decreases the B...

Physical forces activate apoptosis and gene expression, but the mechanism is unknown. For this purpose, adult myocytes were stretched in an equibiaxial str...

A Leri，PP Claudio，Q Li，... - 《Journal of Clinical Investigation》

Sizing up the heart: development redux in disease

A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields

Olson，N E. - 《Genes & Development》

Ventricular Myocytes Are Not Terminally Differentiated in the Adult Mammalian Heart

Circ Res. 1998 Jul 13;83(1):1-14. Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review

P Anversa，J Kajstura - 《Circulation Research》

CYTOPLASMIC SIGNALING PATHWAYS THAT REGULATE CARDIAC HYPERTROPHY.

Determines the cytoplasmic signaling pathways that regulate cardiac hypertrophy. Role of G proteins in cardiac hypertrophy; Evidence of a Ras-dependent sig...

Molkentin，Jeffery，D，... - 《Annual Review of Physiology》

Cyclin D1 overexpression promotes cardiomyocyte DNA synthesis and multinucleation in transgenic mice.

D-type cyclin/cyclin-dependent kinase (CDK) complexes regulate transit through the restriction point of the cell cycle, and thus are required for the initi...

MH Soonpaa，KK Kim，LJ Field - 《Journal of Clinical Investigation》

Insulin-Like Growth Factor-1 Attenuates the Detrimental Impact of Nonocclusive Coronary Artery Constriction on the Heart

Coronary artery narrowing (CAN) induces tissue injury, which may involve myocyte and . -like growth factor ()-1 may counteract , modifying the detrimental ...

B Li，M Setoguchi，X Wang，... - 《Circulation Research》

Regulation of cardiac growth and coronary angiogenesis by the Akt/PKB signaling pathway.

Postnatal growth of the heart is primarily achieved through hypertrophy of individual myocytes. Cardiac growth observed in athletes represents adaptive or ...

I Shiojima，K Walsh - 《Genes & Development》