Characteristics of a soluble nuclear antigen precipitating with sera of patients with systemic lupus erythematosus.
摘要：
Sera of patients with systemic lupus erythematosus were demonstrated to contain precipitating antibodies to soluble tissue components other than DNA. One dominant reaction was observed which was provisionally termed the Sm system. The antigen involved was identified in nuclei of a wide variety of cells from different species. It was associated with protein fractions but was a non-histone substance quite sensitive to periodate treatment. Antibodies to the Sm antigen could also be detected by complement fixation. They showed a high incidence in systemic lupus erythematosus with considerable specificity for the disease.
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DOI：
10.1681/ASN.2008121225
被引量：
年份：
1966
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来源期刊
Journal of Immunology
1966 Mar;
引用走势
2010
被引量：60
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