Protein-Tyrosine Kinase
摘要：
The control of enzyme activity by reversible phosphorylation and the role of protein kinases in signal transduction illustrate well the pivotal role of protein phosphorylation in cell regulation. There are numerous examples of the role of protein kinases and phosphatases in disease, and protein kinases in particular are now established as druggable therapeutic targets (1). Phosphoproteomics includes the large-scale determination of protein phosphorylation in cells and tissue, sometimes referred to as phosphoprofiling. Phosphoprofiling is a global approach that can be used to characterize biological states including therapeutic responses. It is augmented by another proteomic method, protein kinase (and protein phosphatase) interaction mapping, which together have the
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关键词：
Animals Humans Tyrosine Threonine Serine Viral Proteins Protein Kinases Receptor, Epidermal Growth Factor Oncogene Protein pp60(v-src Receptors, Cell Surface
DOI：
10.1146/annurev.bi.54.070185.004341
被引量：
年份：
1985
Taylor & Francis
dx.doi.org
Annual Reviews
NCBI
Europe PMC
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