The effects of small-dose ketamine on propofol sedation: respiration, postoperative mood, perception, cognition, and pain.

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作者：

RF Mortero，LD Clark，MM Tolan，RJ Metz，K Tsueda，RA Sheppard

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摘要：

We compared the effects of coadministration of and small-dose ketamine to alone on respiration during monitored anesthesia care. In addition, mood, perception, and in the recovery room, and pain after discharge were evaluated. In the group (n = 20), patients received 38 +/- 24 microg x kg(-1) x min(-1). The Coadministration group (n = 19) received 33 +/- 13 microg x kg(-1) x min(-1) and ketamine 3.7 +/- 1.5 microg x kg(-1) x min(-1). Respiration was assessed by using end-expiratory (2) measurements at nasal prongs. After surgeries, mood, perception, and thought were assessed by using visual analog scales, and was assessed by Mini-Mental State Examination (MMSE). Pain after discharge was assessed by a five-point rating scale in the evening for 5 days. End-expiratory (2) was lower in the Coadministration group (P < 0.0001). Mood and MMSE scores were higher in the Coadministration group (P < 0.004 and P = 0.001, respectively). Pain scores and consumption after discharge were less in the Coadministration group (P = 0.0004 and P < 0.0001, respectively). We conclude that coadministration of small-dose ketamine attenuates -induced hypoventilation, produces positive mood effects without perceptual changes after surgery, and may provide earlier recovery of .

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关键词：

near-infrared spectroscopy aortic arch surgery cerebral ischemia

DOI：

10.1097/00000539-200106000-00022

被引量：

320

年份：

2001