Induction of tolerance to an IgG autoantibody
摘要：
Nonautoimmune mice transgenic for the heavy chain of an IgG2b anti-double-stranded-DNA antibody express the transgene in lymphoid organs and display partial allelic exclusion of this γ2b transgene. The spleens of these mice are characterized by marked B-cell depletion. Although there are B cells in these mice that express the transgene and recognize double-stranded DNA, they are anergic in vivo. Recovery from the state of anergy occurs in vitro after lipopolysaccharide stimulation. Thus this transgenic model demonstrates the induction of self tolerance to an IgG autoantibody.
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DOI：
10.1073/pnas.89.17.8332
被引量：
年份：
1992
万方医学
Semantic Scholar
掌桥科研
dx.doi.org
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