摘要：

Purpose: Tissue conditioners contain various types of phthalic esters as plasticizers. A recent study reported that these phthalic esters would have estrogenicity. The aim of this study was to identify and quantify the leached plasticizers from tissue conditioners.Methods: Three different tissue conditioners were immersed in distilled water and artificial saliva for up to 14 days. Cumulative plasticizer leaching in each immersion medium was measured at days 1, 3, 5, 7, and 14. Following each storage period, leached plasticizer was extracted with hexane and analyzed by high-performance liquid chromatography (HPLC).Results: Leaching of plasticizer increased with longer immersion durations for up to 14 days. There was a significant difference between the leaching rate on first day and those of following immersion periods. The total amount of leached plasticizer in artificial saliva (15.1-39.4mg/g) was higher than that in distilled water (11.8-30.7mg/g). Benzyl benzoate showed the highest value of the amount of leached plasticizer, and butyl phthalyl butyl glycolate showed the lowest value, under both immersing conditions. Based on the total amount of leached plasticizer for 14 days, the daily amount of leached plasticizer was calculated as benzyl benzoate, 2.19; dibuty phthalate, 1.60; and butyl phthalyl butyl glycolate, 0.84mg/g/day, in distilled water; and benzyl benzoate, 2.81; dibutyl phthalate, 1.76; and butyl phthalyl butyl glycolate, 1.08mg/g/day, in artificial saliva.Conclusions: The results of this study suggested that the amount of leached plasticizer was dependent on the type of plasticizer (molecular weight and chemical structure). The daily amount of leached dibutyl phthalate would be 20 times greater than food uptake.

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