Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction.
摘要：
The Spemann organizer in amphibian embryos is a tissue with potent head-inducing activity, the molecular nature of which is unresolved. Here we describe dickkopf-1 (dkk-1), which encodes Dkk-1, a secreted inducer of Spemann's organizer in Xenopus and a member of a new protein family. Injections of mRNA and antibody indicate that dkk-1 is sufficient and necessary to cause head induction. dkk-1 s a potent antagonist of Wnt signalling, suggesting that dkk genes encode a family of secreted Wnt inhibitors.
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关键词：
Embryonic Induction Proteins Proto-Oncogene Proteins proto oncogene protein int-1 胚胎诱导 蛋白质类 原癌基因蛋白质类
DOI：
10.1038/34848
被引量：
年份：
1998
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掌桥科研
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