The Novel Role of Platelet-Activating Factor in Protecting Mice against Lipopolysaccharide-Induced Endotoxic Shock
摘要：
Background: Platelet-activating factor (PAF) has been long believed to be associated with many pathophysiological processes during septic shock. Here we present novel activities for PAF in protecting mice against LPS-mediated endotoxic shock. Principal Findings: In vivo PAF treatment immediately after LPS challenge markedly improved the survival rate against mortality from endotoxic shock. Administration of PAF prominently attenuated LPS-induced organ injury, including profound hypotension, excessive polymorphonuclear neutrophil infiltration, and severe multiple organ failure. In addition, PAF treatment protects against LPS-induced lymphocytes apoptosis. These protective effects of PAF was correlated with significantly decreases in the production of the inflammatory mediators such as TNF-α, IL-1β, IL-12, and IFN-γ, while increasing production of the anti-inflammatory cytokine IL-10 in vivo and in vitro. Conclusions: Taken together, these results suggest that PAF may protect mice against endotoxic shock via a complex mechanism involving modulation of inflammatory and anti-inflammatory mediators.
展开
DOI：
10.1371/journal.pone.0006503
被引量：
年份：
2009
EBSCO
Semantic Scholar
掌桥科研
万方医学
Semantic Scholar
(全网免费下载)
查看更多
dx.doi.org
Europe PMC
NCBI
Europe PMC
(全网免费下载)
NCBI
NCBI
(全网免费下载)
Oxford Univ Press
OALib
adsabs.harvard.edu
plosone.org
plosone.org
(全网免费下载)
ResearchGate
ProQuest
ResearchGate
(全网免费下载)
Citeseer
(全网免费下载)
EBSCO
EBSCO
journals.plos.org
(全网免费下载)
jlr.org
paperity.org
mendeley.com
学术范
(全网免费下载)
dx.plos.org
core.ac.uk
mailer.oalib.net
scienceopen.com
jimmunol.org
biomedsearch.com
(全网免费下载)
pubfacts.com
dx.plos.org
(全网免费下载)
www.socolar.com
学术范
onAcademic
deepdyve.com
Semantic Scholar
(全网免费下载)
NCBI
(全网免费下载)
Europe PMC
(全网免费下载)
plosone.org
(全网免费下载)
ResearchGate
(全网免费下载)
Citeseer
(全网免费下载)
dx.plos.org
(全网免费下载)
biomedsearch.com
(全网免费下载)
journals.plos.org
(全网免费下载)
学术范
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
