Characterization of chitosan and polycaprolactone membranes designed for wound repair application

来自 EBSCO

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作者：

CL Salgado，EMS Sanchez，JF Mano，AM Moraes

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摘要：

and enthalpy (Δ) were detected by DSC. However, the surfactant increased the Δ. After 30days, the membranes obtained in the presence of PF68 had absorbed more blood serum and were more degraded after exposure to simulated blood fluid for 30days. All membranes had low cytotoxicity, and higher cell proliferation was noticed for samples obtained in the presence of the surfactant. In conclusion, the Ch/PCL membranes showed satisfactory degradability and biocompatibility, which enhances their potential for application in wound repair.

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关键词：

Theoretical or Mathematical, Experimental/ biochemistry biomechanics biomembranes blood cellular biophysics differential scanning calorimetry DNA molecular biophysics polymers proteins scanning electron microscopy swelling viscoelasticity wounds/ chitosan characterization polycaprolactone membranes wound repair application polycaprolactone biodegradable polymers surfactant pluronic F68 thermal behavior viscoelastic properties sample swelling phosphate-buffered saline simulated body fluid fetal bovine serum dynamical mechanical analysis cell toxicity fibroblasts MTT reduction assay cell proliferation DNA quantification confocal laser microscopy scanning electron microscopy SEM melting temperature enthalpy blood serum low cytotoxicity higher cell proliferation biocompatibility/ A8725F Physics of subcellular structures A8745 Biomechanics, biorheology, biological fluid dynamics A8715D Physical chemistry of biomolecular solutions and condensed states A8715M Interactions with