Different roles of the IGF-I Ec peptide (MGF) and mature IGF-I in myoblast proliferation and differentiation
摘要：
The physiological function of a recently cloned splice variant of insulin-like growth factor-I (IGF-I; mechano growth factor (MGF)) was studied using an in vitro cell model. Unlike mature IGF-I, the distinct E domain of MGF inhibits terminal differentiation whilst increasing myoblast proliferation. Blocking the IGF-I receptor with a specific antibody indicated that the function of MGF E domain is mediated via a different receptor. The results provide a basis for localized tissue adaptation and helps explain why loss of muscle mass occurs in the elderly and in dystrophic muscle in which MGF production is markedly affected.
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关键词：
Insulin-like growth factor-I splice variant Muscle differentiation Proliferation C2C12 myoblast
DOI：
10.1016/j.febslet.2006.04.001
被引量：
年份：
2002
Elsevier
BMJ
Wiley
dx.doi.org
Ingenta
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