The pathogenesis of influenza in humans
摘要：
However, the mechanism of pathogenicity may differ in highly pathogenic strains of human influenza, such as the H1N1 pandemic strain of 1918 and the H5N1 strain involved in the outbreak in Hong Kong in 1997. Binding of host proteases by the viral neuraminidase to assist activation of the haemagglutinin, shortening of the neuraminidase and substitutions in the polymerase gene, PB2, have all been suggested as alternative molecular correlates of pathogenicity of human influenza viruses. Additionally, systemic spread in humans of pathogenic subtypes has not been demonstrated and host factors such as interferons may be crucial in preventing the spread of the virus outside the respiratory tract. Copyright ? 2001 John Wiley & Sons, Ltd.
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关键词：
Animals Humans Orthomyxoviridae Hemagglutinin Glycoproteins, Influenza Virus Disease Reservoirs Evolution, Molecular Antigenic Variation Influenza, Human Neuraminidase Birds
DOI：
10.1002/rmv.319
被引量：
年份：
2010
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