Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors.

In this study, we report the isolation from canine intestines of 2-arachidonyl glycerol (2-Ara-Gl). Its structure was determined by mass spectrometry and b...

R Mechoulam，S Ben-Shabat，L Hanus，... - 《Biochemical Pharmacology》

Pharmacology of cannabinoid CB1 and CB2 receptors.

There are at least two types of cannabinoid receptors, CB1 and CB2, both coupled to G-proteins. CB1 receptors are present in the central nervous system and...

RG Pertwee - 《Pharmacol Ther》

2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor

Two types of endogenous cannabinoid-receptor agonists have been identified thus far. They are the ethanolamides of polyun-saturated fatty acids-arachidonoy...

L Hanuš，S Abulafi，E Fride，... - 《Proc Natl Acad Sci U S A》

An endogenous cannabinoid (2-AG) is neuroprotective after brain injury.

Traumatic brain injury triggers the accumulation of harmful mediators that may lead to secondary damage. Protective mechanisms to attenuate damage are also...

D Panikashvili，C Simeonidou，S Ben-Shabat，... - 《Nature》

Anandamide induces overeating: mediation by central cannabinoid (CB1) receptors

Rationale : Central cannabinoid systems have been implicated in appetite regulation by the respective hyperphagic actions of exogenous cannabinoids, such a...

CM Williams，TC Kirkham - 《Psychopharmacology》

Platelet- and macrophage-derived endogenous cannabinoids are involved in endotoxin-induced hypotension

Macrophages are the primary cellular targets of bacterial lipopolysaccharide (LPS), but the role of macrophage-derived cytokines in LPS-induced septic shoc...

V Károly，JA Wagner，BD Troy，... - 《Faseb Journal》

Activation of peripheral CB1 cannabinoid receptors in haemorrhagic shock.

Anandamide, an endogenous cannabinoid ligand, binds to CB1 cannabinoid receptors in the brain and mimics the neurobehavioural actions of marijuana. Cannabi...

J Wagner - 《Nature》

N-Acylethanolamines and precursor phospholipids - relation to cell injury.

The present review focuses on the relationship between formation of N-acylethanolamine phospholipids (NAPEs) and N-acyletransferase (NAEs) catalyzed by N-a...

HS Hansen，B Moesgaard，HH Hansen，... - 《Chemistry & Physics of Lipids》

N-acyl-dopamines: novel synthetic CB1 cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo

We reported previously that synthetic amides of polyunsaturated fatty acids with bioactive amines can result in substances that interact with proteins of t...

T Bisogno，D Melck，MY Bobrov，... - 《Biochemical Journal》

Synthesis and Characterization of Potent and Selective Agonists of the Neuronal Cannabinoid Receptor (CB1)

Two subtypes of the cannabinoid receptor (CB1 and CB2) are expressed in mammalian tissues. Although selective antagonists are available for each of the sub...

CJ Hillard - 《Journal of Pharmacology & Experimental Therapeutics》