Integrin-associated protein (CD47) and its ligands.
摘要：
Integrin-associated protein (IAP or CD47) is a receptor for thrombospondin family members, a ligand for the transmembrane signaling protein SIRPα and a component of a supramolecular complex containing specific integrins, heterotrimeric G proteins and cholesterol. Peptides containing a VVM motif in the C-terminal domain of thrombospondins are agonists for CD47, initiating heterotrimeric Gi protein signaling that augments the functions of integrins of the β1, β2 and β3 families, thus modulating a range of cell activities including platelet activation, cell motility and adhesion, and leukocyte adhesion, migration and phagocytosis.
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关键词：
Integrin Cell signalling LAP/CD47 Integrin-associated protein Cholesterol Protein complex Thrombospondin (TSP Membrane GTPase G protein
DOI：
10.1016/S0962-8924(00)01906-1
被引量：
年份：
2001
Elsevier
掌桥科研
万方医学
dx.doi.org
Ingenta
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