Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor
摘要：
Interleukin-6 (IL-6/BSF-2/IFN beta 2) is a multifunctional cytokine that regulates the growth and differentiation of various tissues, and is known particularly for its role in the immune response and acute phase reactions. A complementary DNA encoding the human IL-6 receptor (IL-6-R) has now been isolated. The IL-6-R consists of 468 amino acids, including a signal peptide of approximately 19 amino acids and a domain of approximately 90 amino acids that is similar to a domain in the immunoglobulin (Ig) superfamily. The cytoplasmic domain of approximately 82 amino acids lacks a tyrosine/kinase domain, unlike other growth factor receptors.
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关键词：
Humans Cell Line DNA Receptors, Immunologic Receptors, Interleukin-6 Cloning, Molecular Base Sequence Sequence Homology, Nucleic Acid Transcription, Genetic Amino Acid Sequence
DOI：
10.1126/science.3136546
被引量：
年份：
1988
万方医学
NCBI
JSTOR
Oxford Univ Press
Cell Press
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