Identification of katanin, an ATPase that severs and disassembles stable microtubules
摘要：
Eukaryotic cells rapidly reorganize their microtubule cytoskeleton during the cell cycle, differentiation, and cell migration. In this study, we have purified a heterodimeric protein, katanin, that severs and disassembles microtubules to tubulin dimers. The disassembled tubulin can repolymerize, indicating that it is not irreversibly modified or denatured in the reaction. Katanin is a microtubule-stimulated ATPase and requires ATP hydrolysis to sever microtubules. Katanin represents a novel type of enzyme that utilizes energy from nucleotide hydrolysis to break tubulin-tubulin bonds within a microtubule polymer, a process that may aid in disassembling complex microtubule arrays within cells.
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关键词：
Robust control LQR Confidence region Covariance Weighted H(2) norm Supremum norm H(infinity) norm Tight bound Reproducing kernel
DOI：
10.1016/0092-8674(93)90377-3
被引量：
年份：
1993
Elsevier
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Elsevier
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万方医学
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