Apoptosis and genomic instability
摘要：
Genomic instability is intrinsically linked to significant alterations in apoptosis control. Chromosomal and microsatellite instability can cause the inactivation of pro-apoptotic pathways. In addition, the inhibition of apoptosis itself can be permissive for the survival and ongoing division of cells that have failed to repair DNA double-strand breaks, experience telomere dysfunction or are in an abnormal polyploid state. Furthermore, DNA-repair proteins can regulate apoptosis. So, genomic instability and apoptosis are intimately linked phenomena, with important implications for the pathophysiology of cancer.
展开
关键词：
MITOTIC CATASTROPHE DNA-DAMAGE CELL-DEATH TELOMERE DYSFUNCTION DEPENDENT APOPTOSIS BARRETTS-ESOPHAGUS CHECKPOINT KINASE HUMAN FIBROBLASTS COLON-CARCINOMA HISTONE H2AX
DOI：
10.1038/nrm1443
被引量：
年份：
2004
Nature
(全网免费下载)
Nature
Springer
国家科技图书文献中心
(权威机构)
万方
查看更多
EBSCO
掌桥科研
万方医学
Semantic Scholar
dx.doi.org
Ingenta
Europe PMC
NCBI
NCBI
NRC Research Press
ResearchGate
(全网免费下载)
ResearchGate
ProQuest
EBSCO
EBSCO
jcs.biologists.org
web.stanford.edu
(全网免费下载)
mysciencework.com
onAcademic
molbiolcell.org
deepdyve.com
pubfacts.com
scienceopen.com
go.galegroup.com
istina.msu.ru
embor.embopress.org
mendeley.com
readcube.com
mcr.aacrjournals.org
www.socolar.com
reproduction-online.org
钛学术
钛学术
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
来源期刊
引用走势
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
