Enzymatic production of glycolic acid

阅读量:

36

申请(专利)号:

US12210618

申请日期:

20080915

公开/公告号:

US07638617B2

公开/公告日期:

20091229

申请(专利权)人:

Robert DiCosimo Anna Panova Daniel P. O'Keefe Jeffery Scott Thompson Mark S. Payne

国省代号:

US,US,US,US,US

被引量:

64

摘要:

Various methods are provided for the enzymatic production of glycolic acid from glycolonitrile. These methods include: 1) use of 72W nitrilase mutants having improved nitrilase activity for converting glycolonitrile to glycolic acid, and 2) methods to improve catalyst stability and/or productivity. The methods to improve catalyst stability/productivity include use of reaction stabilizers, running the reactions under substantially oxygen free conditions, and controlling the concentration of substrate in the reaction mixture.

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引用走势

2011
被引量:18

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0

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