Enzymatic production of glycolic acid
申请(专利)号:
US12210618
申请日期:
20080915
公开/公告号:
US07638617B2
公开/公告日期:
20091229
申请(专利权)人:
Robert DiCosimo Anna Panova Daniel P. O'Keefe Jeffery Scott Thompson Mark S. Payne
国省代号:
US,US,US,US,US
被引量:
摘要:
Various methods are provided for the enzymatic production of glycolic acid from glycolonitrile. These methods include: 1) use of 72W nitrilase mutants having improved nitrilase activity for converting glycolonitrile to glycolic acid, and 2) methods to improve catalyst stability and/or productivity. The methods to improve catalyst stability/productivity include use of reaction stabilizers, running the reactions under substantially oxygen free conditions, and controlling the concentration of substrate in the reaction mixture.
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