Coordination of PIC Assembly and Chromatin Remodeling During Differentiation-Induced Gene Activation
摘要：
We analyzed the ordered recruitment of factors to the human α1antitrypsin promoter around the initial activation of the gene during enterocyte differentiation. We found that a complete preinitiation complex, including phosphorylated RNA pol II, was assembled at the promoter long before transcriptional activation. The histone acetyltransferases CBP and P/CAF were recruited subsequently, but local histone hyperacetylation was delayed. After transient recruitment of the human Brahma homolog hBrm, remodeling of the neighboring nucleosome coincided with transcription initiation. The results suggest that, at this promoter, chromatin reconfiguration is a defining step of the initiation process, acting after the assembly of the Pol II machinery.
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关键词：
polymer bonded explosives (PBXs HMX environmental scanning electron microscope (ESEM highly filled composite energetic materials
DOI：
10.1126/science.1068356
被引量：
年份：
2002
万方医学
Semantic Scholar
dx.doi.org
Cell Press
Oxford Univ Press
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