Cell proliferation in human coronary arteries.
摘要：
Despite the lack of direct evidence for cell multiplication, proliferation of smooth muscle cells in human atherosclerotic lesions has been assumed to play a central role in ontogeny of the plaque. We used antibodies to cell cycle-related proteins on tissue sections of human arteries and coronary atherosclerotic plaques. Specific cell types were identified by immunochemical reagents for smooth muscle, monocyte-macrophages, and other blood cells. Low rates of smooth muscle cell proliferation were observed. Macrophages were also observed with rates of proliferation comparable to that of the smooth muscle. Additional replicating cells could not be defined as belonging to specific cell types with the reagents used in this study. These findings imply that smooth muscle replication in advanced plaques is indolent and raise the possibility of a role for proliferating leukocytes.
展开
DOI：
10.1073/pnas.87.12.4600
被引量：
Taylor & Francis
BMJ
Semantic Scholar
万方医学
掌桥科研
查看更多
doi.org
dx.doi.org
Europe PMC
(全网免费下载)
NCBI
NCBI
(全网免费下载)
JSTOR
Oxford Univ Press
NCBI
Europe PMC
JBC
adsabs.harvard.edu
ResearchGate
EBSCO
SAGE
deepdyve.com
osti.gov
core.ac.uk
学术范
(全网免费下载)
onlinecjc.ca
fasebj.org
jleukbio.org
onAcademic
pnas.org
mendeley.com
The National Academy of Sciences of the United States of America
(全网免费下载)
jlr.org
atvb.ahajournals.org
ajpcell.physiology.org
jpet.aspetjournals.org
pnas.org
(全网免费下载)
jimmunol.org
f1000.com
diabetes.diabetesjournals.org
学术范
Europe PMC
(全网免费下载)
NCBI
(全网免费下载)
学术范
(全网免费下载)
pnas.org
(全网免费下载)
The National Academy of Sciences of the United States of America
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
