Recombinant human tumor necrosis factor-alpha: effects on proliferation of normal and transformed cells in vitro
摘要：
Modulation of the growth of human and murine cell lines in vitro by recombinant human tumor necrosis factor-alpha (rTNF-alpha) and recombinant human interferon-gamma (rIFN-gamma) was investigated. rTNF-alpha had cytostatic or cytolytic effects on only some tumor cell lines. When administered together with rIFN-gamma, rTNF-alpha showed enhanced antiproliferative effects on a subset of the cell lines tested. In contrast to its effects on sensitive tumor cells, rTNF-alpha augmented the growth of normal diploid fibroblasts. Variations in the proliferative response induced by rTNF-alpha were apparently not due to differences in either the number of binding sites per cell or their affinity for rTNF-alpha. These observations indicate that the effects of rTNF-alpha on cell growth are not limited to tumor cells, but rather that this protein may have a broad spectrum of activities in vivo.
展开
关键词：
Animals Humans Mice Cell Line Cell Transformation, Neoplastic Glycoproteins Recombinant Proteins Drug Synergism Cell Division Cell Survival
DOI：
10.1126/science.3933111
被引量：
年份：
1985
BMJ
万方医学
dx.doi.org
Wolters Kluwer
JSTOR
查看更多
NCBI
NCBI
Europe PMC
JBC
AACR
adsabs.harvard.edu
ProQuest
ResearchGate
(全网免费下载)
ResearchGate
EBSCO
mendeley.com
jasn.asnjournals.org
efortopenreviews.org
jleukbio.org
fertstert.org
onacademic.com
SAGE
jn.nutrition.org
cghjournal.org
theriojournal.com
cgp.iiarjournals.org
jacionline.org
molpharm.aspetjournals.org
jvi.asm.org
sciencemag.org
erj.ersjournals.com
emboj.embopress.org
readcube.com
ajpgi.physiology.org
biolreprod.org
jimmunol.org
ganino.com
(全网免费下载)
nutrition.highwire.org
molbiolcell.org
mdanderson.influuent.utsystem.edu
nejm.org
www.socolar.com
deepdyve.com
jrheum.org
pubmed.com
ResearchGate
(全网免费下载)
ganino.com
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
