Anti-Influenza virus drug design: Sialidase inhibitors
摘要：
This review will give an overview of the design process behind the development of sialidase inhibitors, which can be used as anti-influenza drugs. Two drugs (Relenza™ and Tamiflu™) are already available as prescription drugs and a third (BCX-1812) is currently undergoing third-phase clinical trials. Also, the use of molecular-modelling techniques in the understanding of the mechanism and the prediction of inhibition of this enzyme is reviewed.
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DOI：
10.1071/ch01173
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年份：
2001
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2002
被引量：10
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