Selective Neurotoxic Lesions of Descending Serotonergic and Noradrenergic Pathways in the Rat

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作者：

Odd-Geir，Berge，Ole，Bernt，Fasmer，Lars，Tveiten，Kjell，Hole

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摘要：

The ability of neurotoxic substances to induce selective lesions of the descending monoaminergic pathways in rats was investigated. Saline, 6-hydroxydopamine, 5,6-dihydroxytryptamine, or 5,7-dihydroxytryp tamine were administered into the lumbar subarachnoid space through a chronically indwelling catheter. The lesions were evaluated 2–3 weeks later by in vitro uptake of [3H]noradrenaline and [14C]5-hydroxytryptamine into synaptosomal preparations from the frontal cortex, brain stem, cervical spinal cord, and lumbar spinal cord of each animal. There was no difference in uptake between saline-injected and noncatheterized controls and no significant changes in cortcial uptake after any of the treatments (dose range of neurotoxins: 0.6–80 μg). In the lumbar spinal cord, 6-hydroxydopamine (5–80 μg) reduced the [3H]noradrenaline uptake by approximately 90% with no effects on [14C]5-hydroxytryptamine uptake, wherea

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关键词：

6-Hydroxydopamine 5,6-Dihydroxytryptamine 5,7-Dihydroxytryptamine Neurotoxic lesions Noradrenaline 5-Hydroxytryptamine

DOI：

10.1111/j.1471-4159.1985.tb08738.x

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年份：

1985