摘要：

The Ectonucleotide Pyrophosphatase/Phosphodiesterase type 2 (), more commonly known as (), is an -D () encoded by the ENNP2 gene. is expressed in multiple tissues and participates in numerous key physiologic and including neural development, , inflammation, and through the generation of the bioactive (). Overwhelming evidence indicates that altered activity leads to and through the modulation of multiple hallmarks of pathobiology. Here, we review the structural and catalytic characteristics of the ectoenzyme, how its expression and maturation processes are regulated, and how the systemic integration of its pleiomorphic effects on and tissues may contribute to initiation, progression, and therapy. Additionally, the up-to-date spectrum of the most frequent genomic alterations from The Genome (TCGA) project is reported for a subset of .

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